Keys to the Game:
Indianapolis: Lynch showed you can run on this 49er defense and Richardson will try and give the Colts that platform.
San Francisco: Look for Anquan Boldin to bounce back early after the horror show in Seattle.
Verdict: The Colts are getting a very angry 49er team and with or without Trent Richardson there is only one winner here.
Prediction: San Francisco by 13
Suggested Bet: No bet
Betting and Fantasy Tips 